Soluble urokinase plasminogen activator receptor levels reflect organ damage in systemic lupus erythematosus

Soluble urokinase plasminogen activator receptor levels reflect organ damage in systemic lupus erythematosus.

Assessments of disease activity and organ damage in systemic lupus erythematosus (SLE) remain challenging because of the lack of reliable biomarkers and disease heterogeneity. Ongoing inflammation can be difficult to distinguish from permanent organ damage caused by previous flare-ups or medication side effects. Circulating soluble urokinase plasminogen activator receptor (suPAR) has emerged as...

Soluble urokinase plasminogen activator receptor--a valuable biomarker in systemic lupus erythematosus?

Systemic lupus erythematosus (SLE) is a potentially severe autoimmune condition with an unpredictable disease course, often with fluctuations in disease activity over time. Long term inflammation and drug-related side-effects may subsequently lead to permanent organ damage, a consequence which is intimately connected to decreased quality of life and mortality. New lupus biomarkers that convey i...

Soluble urokinase plasminogen activator receptor (suPAR) in the emergency department: An update

Background: The biomarker soluble urokinase plasminogen activator receptor (suPAR) is an indicator of inflammation which is increased in a variety of chronic and acute disease states. Its most promising application in the emergency setting is to aid in the prognostic stratification of patients by identifying those at high risk of deterioration. This is a narrative review of studies evaluating t...

Increased Serum Levels of Soluble B7-H4 in Patients with Systemic Lupus Erythematosus

evaluation of diagnostic value of soluble urokinase-type plasminogen activator receptor in sepsis

background sepsis is one of the most important causes of morbidity and mortality in the intensive care units (icus). it is difficult to accurately differentiate sepsis from similar diseases rapidly. therefore, it becomes critical to identify any biomarker with the ability of differentiation between sepsis and nonsepsis conditions. the urokinase plasminogen activator receptor has been implicated...